Genetic Counseling and Testing for Colorectal Cancer in Young Adults: Mini-Review by Ethem Unal in Peer Reviewed Journal of Forensic & Genetic Sciences (PRJFGS) in Lupine Publishers
Colorectal
cancer (CRC) has one of the largest proportions of familial cases. Two to 5% of
all colon cancers arise in the setting of inherited syndromes, including Lynch
syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), familial
adenomatous polyposis (FAP), attenuated FAP, MUTYH-associated polyposis (MAP),
and certain hamartomatous polyposis conditions like Peutz-Jeghers syndrome
(PJS) and juvenile polyposis syndrome (JPS). All of these conditions are
inherited, autosomal dominant disorders, except MAP, which is autosomal
recessive [l]. Although clinical similarities do exist, each has different
cancer risks, characteristic clinical features, and separate genetical
etiologies. In addition to these syndromes, up to 30 % of colon cancers exhibit
increased familial risk, likely related to inheritance. A number of less
penetrant, but possibly more frequent susceptibility genes have been identified
for this level of inheritance.
For more Lupine Publishers Open Access Journals please visit our website
For more Genetics Journal articles please click here